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Comprehensive Structure–Activity Profiling of Micheliolide and its Targeted Proteome in Leukemia Cells via Probe-Guided Late-Stage C–H Functionalization

[Image: see text] The plant-derived sesquiterpene lactone micheliolide was recently found to possess promising antileukemic activity, including the ability to target and kill leukemia stem cells. Efforts toward improving the biological activity of micheliolide and investigating its mechanism of acti...

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Detalhes bibliográficos
Publicado no:ACS Cent Sci
Main Authors: Alwaseem, Hanan, Giovani, Simone, Crotti, Michele, Welle, Kevin, Jordan, Craig T., Ghaemmaghami, Sina, Fasan, Rudi
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2021
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8161485/
https://ncbi.nlm.nih.gov/pubmed/34079900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.0c01624
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