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Enhancing the Efficiency and Regioselectivity of P450 Oxidation Catalysts via Unnatural Amino Acid Mutagenesis

The development of effective strategies for modulating the reactivity and selectivity of cytochrome P450 enzymes represents a key step toward expediting the use of these biocatalysts for synthetic applications. In this work, we investigated the potential of unnatural amino acid mutagenesis to aid ef...

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Detalhes bibliográficos
Main Authors: Kolev, Joshua N., Zaengle, Jacqueline M., Ravikumar, Rajesh, Fasan, Rudi
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4059402/
https://ncbi.nlm.nih.gov/pubmed/24692265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201400060
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