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Mechanism-Guided Design and Discovery of Efficient Cytochrome P450-Derived C—H Amination Biocatalysts
Cytochromes P450 have been recently identified as a promising class of biocatalysts for mediating C—H aminations via nitrene transfer, a valuable transformation for forging new C—N bonds. The catalytic efficiency of P450s in these non-native transformations is however significantly inferior to that...
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| Publicado no: | J Am Chem Soc |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7372717/ https://ncbi.nlm.nih.gov/pubmed/32407077 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b12859 |
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