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Targeting NF-κB p65 with a Helenalin Inspired Bis-electrophile
The canonical NF-κB signaling pathway is a mediator of the cellular inflammatory response and a target for developing therapeutics for multiple human diseases. The furthest downstream proteins in the pathway, the p50/p65 transcription factor heterodimer, have been recalcitrant towards small molecule...
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| Publicado no: | ACS Chem Biol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5357558/ https://ncbi.nlm.nih.gov/pubmed/28103680 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00751 |
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