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Targeting NF-κB p65 with a Helenalin Inspired Bis-electrophile

The canonical NF-κB signaling pathway is a mediator of the cellular inflammatory response and a target for developing therapeutics for multiple human diseases. The furthest downstream proteins in the pathway, the p50/p65 transcription factor heterodimer, have been recalcitrant towards small molecule...

詳細記述

保存先:
書誌詳細
出版年:ACS Chem Biol
主要な著者: Widen, John C., Kempema, Aaron M., Villalta, Peter W., Harki, Daniel A.
フォーマット: Artigo
言語:Inglês
出版事項: 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5357558/
https://ncbi.nlm.nih.gov/pubmed/28103680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00751
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