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CH⋯O Hydrogen Bonds Mediate Highly Specific Recognition of Methylated CpG Sites by the Zinc Finger Protein Kaiso

Many eukaryotic transcription factors recognize the epigenetic marker 5-methylcytosine (mC) at CpG sites in DNA. Despite their structural diversity, methyl-CpG-binding proteins (MBPs) share a common mode of recognition of mC methyl groups that involves hydrophobic pockets and weak hydrogen bonds of...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Nikolova, Evgenia N., Stanfield, Robyn L., Dyson, H. Jane, Wright, Peter E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5893398/
https://ncbi.nlm.nih.gov/pubmed/29546986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00065
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