Time-resolved analysis of amino acid stress identifies eIF2 phosphorylation as necessary to inhibit mTORC1 activity in liver

Amino acid availability is sensed by GCN2 (general control nonderepressible 2) and mechanistic target of rapamycin complex 1 (mTORC1), but how these two sensors coordinate their respective signal transduction events remains mysterious. In this study we utilized mouse genetic models to investigate th...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Nikonorova, Inna A., Mirek, Emily T., Signore, Christina C., Goudie, Michael P., Wek, Ronald C., Anthony, Tracy G.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2018
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5892569/
https://ncbi.nlm.nih.gov/pubmed/29449374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001625
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