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Amino Acids Regulate mTORC1 by an Obligate Two-step Mechanism

The mechanistic target of rapamycin complex 1 (mTORC1) coordinates cell growth with its nutritional, hormonal, energy, and stress status. Amino acids are critical regulators of mTORC1 that permit other inputs to mTORC1 activity. However, the roles of individual amino acids and their interactions in...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Dyachok, Julia, Earnest, Svetlana, Iturraran, Erica N., Cobb, Melanie H., Ross, Elliott M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5077182/
https://ncbi.nlm.nih.gov/pubmed/27587390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.732511
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