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CUCURBITACIN D IS A DISRUPTOR OF THE HSP90 CHAPERONE MACHINERY

Heat shock protein 90 (Hsp90) facilitates the maturation of many newly synthesized and unfolded proteins (clients) via the Hsp90 chaperone cycle, in which Hsp90 forms a heteroprotein complex and relies upon co-chaperones, immunophilins, etc. for assistance in client folding. Hsp90 inhibition has eme...

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Dades bibliogràfiques
Publicat a:J Nat Prod
Autors principals: Hall, Jessica A., Seedarala, Sahithi, Rice, Nichole, Kopel, Lucas, Halaweish, Fathi, Blagg, Brian S. J.
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5892428/
https://ncbi.nlm.nih.gov/pubmed/25756299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jnatprod.5b00054
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