Hsp70/Hsp90 chaperone machinery is involved in the assembly of the purinosome

The de novo biosynthesis of purines is carried out by a highly conserved metabolic pathway that includes several validated targets for anticancer, immunosuppressant, and anti-inflammatory chemotherapeutics. The six enzymes in humans that catalyze the 10 chemical steps from phosphoribosylpyrophosphat...

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Hlavní autoři: French, Jarrod B., Zhao, Hong, An, Songon, Niessen, Sherry, Deng, Yijun, Cravatt, Benjamin F., Benkovic, Stephen J.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2013
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3574928/
https://ncbi.nlm.nih.gov/pubmed/23359685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1300173110
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