N-acetylcysteine and vitamin E rescue animal longevity and cellular oxidative stress in preclinical models of mitochondrial complex I disease

Oxidative stress is a known contributing factor in mitochondrial respiratory chain (RC) disease pathogenesis. Yet, no efficient means exists to objectively evaluate the comparative therapeutic efficacy or toxicity of different antioxidant compounds empirically used in human RC disease. We postulated...

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Detalhes bibliográficos
Publicado no:Mol Genet Metab
Main Authors: Polyak, Erzsebet, Ostrovsky, Julian, Peng, Min, Dingley, Stephen D., Tsukikawa, Mai, Kwon, Young Joon, McCormack, Shana, Bennett, Michael, Xiao, Rui, Seiler, Christoph, Zhang, Zhe, Falk, Marni J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5891356/
https://ncbi.nlm.nih.gov/pubmed/29526616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymgme.2018.02.013
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