Combinatorial glucose, nicotinic acid and N-acetylcysteine therapy has synergistic effect in preclinical C. elegans and zebrafish models of mitochondrial complex I disease

Mitochondrial respiratory chain disorders are empirically managed with variable antioxidant, cofactor and vitamin ‘cocktails’. However, clinical trial validated and approved compounds, or doses, do not exist for any single or combinatorial mitochondrial disease therapy. Here, we sought to pre-clinic...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Hum Mol Genet
Hlavní autoři: Guha, Sujay, Mathew, Neal D, Konkwo, Chigoziri, Ostrovsky, Julian, Kwon, Young Joon, Polyak, Erzsebet, Seiler, Christoph, Bennett, Michael, Xiao, Rui, Zhang, Zhe, Nakamaru-Ogiso, Eiko, Falk, Marni J
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2021
Témata:
General Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8120136/
https://ncbi.nlm.nih.gov/pubmed/33640978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddab059
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky