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Combinatorial glucose, nicotinic acid and N-acetylcysteine therapy has synergistic effect in preclinical C. elegans and zebrafish models of mitochondrial complex I disease

Mitochondrial respiratory chain disorders are empirically managed with variable antioxidant, cofactor and vitamin ‘cocktails’. However, clinical trial validated and approved compounds, or doses, do not exist for any single or combinatorial mitochondrial disease therapy. Here, we sought to pre-clinic...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Guha, Sujay, Mathew, Neal D, Konkwo, Chigoziri, Ostrovsky, Julian, Kwon, Young Joon, Polyak, Erzsebet, Seiler, Christoph, Bennett, Michael, Xiao, Rui, Zhang, Zhe, Nakamaru-Ogiso, Eiko, Falk, Marni J
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8120136/
https://ncbi.nlm.nih.gov/pubmed/33640978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddab059
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