Pharmacologic targeting of sirtuin and PPAR signaling improves longevity and mitochondrial physiology in respiratory chain complex I mutant Caenorhabditis elegans

Mitochondrial respiratory chain (RC) diseases are highly morbid multi-systemic conditions for which few effective therapies exist. Given the essential role of sirtuin and PPAR signaling in mediating both mitochondrial physiology and the cellular response to metabolic stress in RC complex I (CI) dise...

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Publicado en:Mitochondrion
Autores principales: McCormack, Shana, Polyak, Erzsebet, Ostrovsky, Julian, Dingley, Stephen D., Rao, Meera, Kwon, Young Joon, Xiao, Rui, Zhang, Zhe, Nakamaru-Ogiso, Eiko, Falk, Marni J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4447550/
https://ncbi.nlm.nih.gov/pubmed/25744875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mito.2015.02.005
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