Pharmacologic targeting of sirtuin and PPAR signaling improves longevity and mitochondrial physiology in respiratory chain complex I mutant Caenorhabditis elegans

Mitochondrial respiratory chain (RC) diseases are highly morbid multi-systemic conditions for which few effective therapies exist. Given the essential role of sirtuin and PPAR signaling in mediating both mitochondrial physiology and the cellular response to metabolic stress in RC complex I (CI) dise...

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Bibliographic Details
Published in:Mitochondrion
Main Authors: McCormack, Shana, Polyak, Erzsebet, Ostrovsky, Julian, Dingley, Stephen D., Rao, Meera, Kwon, Young Joon, Xiao, Rui, Zhang, Zhe, Nakamaru-Ogiso, Eiko, Falk, Marni J.
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4447550/
https://ncbi.nlm.nih.gov/pubmed/25744875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mito.2015.02.005
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