PARP-1 Inhibition Rescues Short Lifespan in Hyperglycemic C. Elegans And Improves GLP-1 Secretion in Human Cells

TCF7L2 is located at one of the most strongly associated type 2 diabetes loci reported to date. We previously reported that the most abundant member of a specific protein complex to bind across the presumed causal variant at this locus, rs7903146, was poly [ADP-ribose] polymerase type 1 (PARP-1). We...

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Bibliografiska uppgifter
I publikationen:Aging Dis
Huvudupphovsmän: Xia, Qianghua, Lu, Sumei, Ostrovsky, Julian, McCormack, Shana E, Falk, Marni J, Grant, Struan F. A
Materialtyp: Artigo
Språk:Inglês
Publicerad: JKL International LLC 2018
Ämnen:
Orginal Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5772855/
https://ncbi.nlm.nih.gov/pubmed/29392078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14336/AD.2017.0230
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