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Alzheimer’s disease genetics and ABCA7 splicing

Both common and rare polymorphisms within ABCA7 have been associated with Alzheimer’s disease (AD). In particular, the rare AD associated polymorphism rs200538373 was associated with altered ABCA7 exon 41 splicing and an AD risk odds ratio of ~1.9. To probe the role of this polymorphism in ABCA7 spl...

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Detalhes bibliográficos
Publicado no:J Alzheimers Dis
Main Authors: Vasquez, Jared B., Simpson, James F., Harpole, Ryan, Estus, Steven
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5890296/
https://ncbi.nlm.nih.gov/pubmed/28655137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-170872
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