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Genetics of Clusterin Isoform Expression and Alzheimer's Disease Risk
The minor allele of rs11136000 within CLU is strongly associated with reduced Alzheimer's disease (AD) risk. The mechanism underlying this association is unclear. Here, we report that CLU1 and CLU2 are the two primary CLU isoforms in human brain; CLU1 and CLU2 share exons 2–9 but differ in exon...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3323613/ https://ncbi.nlm.nih.gov/pubmed/22506010 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033923 |
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