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Alzheimer’s disease genetics and ABCA7 splicing

Both common and rare polymorphisms within ABCA7 have been associated with Alzheimer’s disease (AD). In particular, the rare AD associated polymorphism rs200538373 was associated with altered ABCA7 exon 41 splicing and an AD risk odds ratio of ~1.9. To probe the role of this polymorphism in ABCA7 spl...

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Bibliografische gegevens
Gepubliceerd in:J Alzheimers Dis
Hoofdauteurs: Vasquez, Jared B., Simpson, James F., Harpole, Ryan, Estus, Steven
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5890296/
https://ncbi.nlm.nih.gov/pubmed/28655137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-170872
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