Structural and mechanistic aspects influencing the ADAM10-mediated shedding of the prion protein

BACKGROUND: Proteolytic processing of the prion protein (PrP(C)) by endogenous proteases generates bioactive membrane-bound and soluble fragments which may help to explain the pleiotropic roles of this protein in the nervous system and in brain diseases. Shedding of almost full-length PrP(C) into th...

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Опубликовано в: :Mol Neurodegener
Главные авторы: Linsenmeier, Luise, Mohammadi, Behnam, Wetzel, Sebastian, Puig, Berta, Jackson, Walker S., Hartmann, Alexander, Uchiyama, Keiji, Sakaguchi, Suehiro, Endres, Kristina, Tatzelt, Jörg, Saftig, Paul, Glatzel, Markus, Altmeppen, Hermann C.
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2018
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5889536/
https://ncbi.nlm.nih.gov/pubmed/29625583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-018-0248-6
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