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Structural and mechanistic aspects influencing the ADAM10-mediated shedding of the prion protein
BACKGROUND: Proteolytic processing of the prion protein (PrP(C)) by endogenous proteases generates bioactive membrane-bound and soluble fragments which may help to explain the pleiotropic roles of this protein in the nervous system and in brain diseases. Shedding of almost full-length PrP(C) into th...
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| Izdano u: | Mol Neurodegener |
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| Glavni autori: | , , , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
BioMed Central
2018
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5889536/ https://ncbi.nlm.nih.gov/pubmed/29625583 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-018-0248-6 |
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