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GPI-anchor signal sequence influences PrP(C) sorting, shedding and signalling, and impacts on different pathomechanistic aspects of prion disease in mice
The cellular prion protein (PrP(C)) is a cell surface glycoprotein attached to the membrane by a glycosylphosphatidylinositol (GPI)-anchor and plays a critical role in transmissible, neurodegenerative and fatal prion diseases. Alterations in membrane attachment influence PrP(C)-associated signaling,...
Zapisane w:
| Wydane w: | PLoS Pathog |
|---|---|
| Główni autorzy: | , , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Public Library of Science
2019
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6334958/ https://ncbi.nlm.nih.gov/pubmed/30608982 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007520 |
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