Secretory pathway retention of mutant prion protein induces p38-MAPK activation and lethal disease in mice

Misfolding of proteins in the biosynthetic pathway in neurons may cause disturbed protein homeostasis and neurodegeneration. The prion protein (PrP(C)) is a GPI-anchored protein that resides at the plasma membrane and may be misfolded to PrP(Sc) leading to prion diseases. We show that a deletion in...

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Published in:Sci Rep
Main Authors: Puig, Berta, Altmeppen, Hermann C., Ulbrich, Sarah, Linsenmeier, Luise, Krasemann, Susanne, Chakroun, Karima, Acevedo-Morantes, Claudia Y., Wille, Holger, Tatzelt, Jörg, Glatzel, Markus
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4847012/
https://ncbi.nlm.nih.gov/pubmed/27117504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep24970
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