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Secretory pathway retention of mutant prion protein induces p38-MAPK activation and lethal disease in mice
Misfolding of proteins in the biosynthetic pathway in neurons may cause disturbed protein homeostasis and neurodegeneration. The prion protein (PrP(C)) is a GPI-anchored protein that resides at the plasma membrane and may be misfolded to PrP(Sc) leading to prion diseases. We show that a deletion in...
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| Udgivet i: | Sci Rep |
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| Main Authors: | , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4847012/ https://ncbi.nlm.nih.gov/pubmed/27117504 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep24970 |
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