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Phase I–II clinical trial design: a state-of-the-art paradigm for dose finding
BACKGROUND: Conventional phase I algorithms for finding a phase-2 recommended dose (P2RD) based on toxicity alone is problematic because the maximum tolerated dose (MTD) is not necessarily the optimal dose with the most desirable risk–benefit trade-off. Moreover, the increasingly common practice of...
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| Publicado no: | Ann Oncol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5888967/ https://ncbi.nlm.nih.gov/pubmed/29267863 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/annonc/mdx795 |
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