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A robust Bayesian dose-finding design for phase I/II clinical trials
We propose a Bayesian phase I/II dose-finding trial design that simultaneously accounts for toxicity and efficacy. We model the toxicity and efficacy of investigational doses using a flexible Bayesian dynamic model, which borrows information across doses without imposing stringent parametric assumpt...
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| Publicado no: | Biostatistics |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5006115/ https://ncbi.nlm.nih.gov/pubmed/26486139 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/biostatistics/kxv040 |
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