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A Phase I-II Basket Trial Design to Optimize Dose-Schedule Regimes Based on Delayed Outcomes
This paper proposes a Bayesian adaptive basket trial design to optimize the dose–schedule regimes of an experimental agent within disease subtypes, called “baskets”, for phase I-II clinical trials based on late-onset efficacy and toxicity. To characterize the association among the baskets and regime...
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| Опубликовано в: : | Bayesian Anal |
|---|---|
| Главные авторы: | , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8277108/ https://ncbi.nlm.nih.gov/pubmed/34267857 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1214/20-ba1205 |
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