Structure of the Insulin Receptor-Insulin Complex by Single Particle CryoEM analysis

The insulin receptor (IR) is a dimeric protein that plays a crucial role in controlling glucose homeostasis, regulating lipid, protein and carbohydrate metabolism, and modulating brain neurotransmitter levels(1,2). IR dysfunctions have been associated with many diseases, including diabetes, cancer,...

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Udgivet i:Nature
Main Authors: Scapin, Giovanna, Dandey, Venkata P., Zhang, Zhening, Prosise, Winifred, Hruza, Alan, Kelly, Theresa, Mayhood, Todd, Strickland, Corey, Potter, Clinton S., Carragher, Bridget
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5886813/
https://ncbi.nlm.nih.gov/pubmed/29512653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature26153
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