LRRK2 G2019S-induced mitochondrial DNA damage is LRRK2 kinase dependent and inhibition restores mtDNA integrity in Parkinson’s disease

Mutations in leucine-rich repeat kinase 2 (LRRK2) are associated with increased risk for developing Parkinson’s disease (PD). Previously, we found that LRRK2 G2019S mutation carriers have increased mitochondrial DNA (mtDNA) damage and after zinc finger nuclease-mediated gene mutation correction, mtD...

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Veröffentlicht in:Hum Mol Genet
Hauptverfasser: Howlett, Evan H, Jensen, Nicholas, Belmonte, Frances, Zafar, Faria, Hu, Xiaoping, Kluss, Jillian, Schüle, Birgitt, Kaufman, Brett A, Greenamyre, J T, Sanders, Laurie H
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2017
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5886254/
https://ncbi.nlm.nih.gov/pubmed/28973664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx320
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