Exclusive expression of MeCP2 in the nervous system distinguishes between brain and peripheral Rett syndrome-like phenotypes

Rett syndrome (RTT) is a severe genetic disorder resulting from mutations in the X-linked MECP2 gene. MeCP2 protein is highly expressed in the nervous system and deficiency in the mouse central nervous system alone recapitulates many features of the disorder. This suggests that RTT is primarily a ne...

Full description

Saved in:
Bibliographic Details
Published in:Hum Mol Genet
Main Authors: Ross, Paul D., Guy, Jacky, Selfridge, Jim, Kamal, Bushra, Bahey, Noha, Tanner, K. Elizabeth, Gillingwater, Thomas H., Jones, Ross A., Loughrey, Christopher M., McCarroll, Charlotte S., Bailey, Mark E.S., Bird, Adrian, Cobb, Stuart
Format: Artigo
Language:Inglês
Published: Oxford University Press 2016
Subjects:
Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5886038/
https://ncbi.nlm.nih.gov/pubmed/28173151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw269
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items