Exclusive expression of MeCP2 in the nervous system distinguishes between brain and peripheral Rett syndrome-like phenotypes

Rett syndrome (RTT) is a severe genetic disorder resulting from mutations in the X-linked MECP2 gene. MeCP2 protein is highly expressed in the nervous system and deficiency in the mouse central nervous system alone recapitulates many features of the disorder. This suggests that RTT is primarily a ne...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Hum Mol Genet
Prif Awduron: Ross, Paul D., Guy, Jacky, Selfridge, Jim, Kamal, Bushra, Bahey, Noha, Tanner, K. Elizabeth, Gillingwater, Thomas H., Jones, Ross A., Loughrey, Christopher M., McCarroll, Charlotte S., Bailey, Mark E.S., Bird, Adrian, Cobb, Stuart
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2016
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5886038/
https://ncbi.nlm.nih.gov/pubmed/28173151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw269
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