A Low-Toxicity DNA-Alkylating N-Mustard-Quinoline Conjugate with Preferential Sequence Specificity Exerts Potent Antitumor Activity Against Colorectal Cancer

Efficacy and safety are fundamental prerequisites for anticancer drug development. In the present study, we explored the anti–colorectal cancer (CRC) activity of SL-1, a DNA-directed N-mustard-quinoline conjugate. The N-mustard moiety in SL-1 induced DNA strand breaks, interstrand cross-links (ICLs)...

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Bibliografski detalji
Izdano u:Neoplasia
Glavni autori: Chen, Tai-Lin, Lin, Yi-Wen, Chen, Yan-Bo, Lin, Jing-Jer, Su, Tsann-Long, Shen, Chia-Ning, Lee, Te-Chang
Format: Artigo
Jezik:Inglês
Izdano: Neoplasia Press 2017
Teme:
Original article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5884014/
https://ncbi.nlm.nih.gov/pubmed/29247884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2017.11.006
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