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Novel liver-specific cholic acid-cytarabine conjugates with potent antitumor activities: Synthesis and biological characterization
AIM: Cytarabine is an efficient anticancer agent for acute myelogenous leukemia, but with short plasma half-life and rapid deamination to its inactive metabolite. The aim of this study was to design and synthesize novel cholic acid-cytarabine conjugates to improve its pharmacokinetic parameters. MET...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4002521/ https://ncbi.nlm.nih.gov/pubmed/21516131 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2011.7 |
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