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Synthesis and Biological Evaluation of New Paclitaxel Analogs and Discovery of Potent Antitumor Agents

Reaction of 10-deacetylbaccatin III (III) and its 7-TES derivative (IV) with DAST under various conditions resulted in the formation of an array of new fluorinated and non-fluorinated 13-keto taxoid compounds (2a–4a) through a vinylogous pinacol-pinacolone rearrangement. Further fluorination of some...

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Bibliografiske detaljer
Main Authors: Nicolaou, Kyriacos C., Valiulin, Roman A.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3712363/
https://ncbi.nlm.nih.gov/pubmed/23685867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3ob40654g
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