Antitumor Agents 288. Design, Synthesis, SAR, and Biological Studies of Novel Heteroatom-Incorporated Antofine and Cryptopleurine Analogs as Potent and Selective Antitumor Agents

Novel heteroatom-incorporated antofine and cryptopleurine analogs were designed, synthesized, and tested against a panel of five cancer cell lines. Two new S-13-oxo analogs (11 and 16) exhibited potent cell growth inhibition in vitro (GI(50): 9 nM and 20 nM). Interestingly, both compounds displayed...

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מידע ביבליוגרפי
Main Authors: Yang, Xiaoming, Shi, Qian, Yang, Shuenn-Chen, Chen, Chi-Yuan, Yu, Sung-Liang, Bastow, Kenneth F., Morris-Natschke, Susan L., Wu, Pei-Chi, Lai, Chin-Yu, Wu, Tian-Shung, Pan, Shiow-Lin, Teng, Che-Ming, Lin, Jau-Chen, Yang, Pan-Chyr, Lee, Kuo-Hsiung
פורמט: Artigo
שפה:Inglês
יצא לאור: 2011
נושאים:
Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3141083/
https://ncbi.nlm.nih.gov/pubmed/21668000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200330s
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