Antitumor Agents 268. Design, Synthesis, and Mechanistic Studies of New 9-Substituted Phenanthrene-based Tylophorine Analogs as Potent Cytotoxic Agents

Nineteen new phenanthrene-based tylophorine analogs with various functional groups on the piperidine moiety were designed, synthesized and evaluated for in vitro anticancer activity against four human tumor cell lines. Analogs 15 and 21 showed approximately two-fold enhanced inhibitory activity as c...

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Detalhes bibliográficos
Main Authors: Yang, Xiaoming, Shi, Qian, Liu, Yi-Nan, Zhao, Guiyu, Bastow, Kenneth F., Lin, Jau-Chen, Yang, Shuenn-Chen, Yang, Pan-Chyr, Lee, Kuo-Hsiung
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2888945/
https://ncbi.nlm.nih.gov/pubmed/19645447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm9009263
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