Antitumor Agents 295. E-ring Hydroxylated Antofine and Cryptopleurine Analogs as Antiproliferative Agents: Design, Synthesis, and Mechanistic Studies

Various E-ring hydroxylated antofine and cryptopleurine analogs were designed, synthesized, and tested against five human cancer cell lines. Interesting structure-activity relationship (SAR) correlations were found among these new compounds. The most potent compound 13b was further tested against a...

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Detalhes bibliográficos
Main Authors: Yang, Xiaoming, Shi, Qian, Lai, Chin Yu, Chen, Chi-Yuan, Ohkoshi, Emika, Yang, Shuenn-Chen, Wang, Chih-Ya, Bastow, Kenneth F., Wu, Tian-Shung, Pan, Shiow-Lin, Teng, Che-Ming, Yang, Pan-Chyr, Lee, Kuo-Hsiung
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422873/
https://ncbi.nlm.nih.gov/pubmed/22823514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm3001218
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