Ibrutinib Exerts Potent Antifibrotic and Antitumor Activities in Mouse Models of Pancreatic Adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is characterized by a dense stromal fibroinflammatory reaction that is a major obstacle to effective therapy. The desmoplastic stroma comprises many inflammatory cells, in particular mast cells as key components of the PDAC microenvironment, and such infiltrat...

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Bibliographic Details
Published in:Cancer Res
Main Authors: Massó-Vallés, Daniel, Jauset, Toni, Serrano, Erika, Sodir, Nicole M., Pedersen, Kim, Affara, Nesrine I., Whitfield, Jonathan R., Beaulieu, Marie-Eve, Evan, Gerard I., Elias, Laurence, Arribas, Joaquín, Soucek, Laura
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6773609/
https://ncbi.nlm.nih.gov/pubmed/25878147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-2852
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