Targeting Antitumoral Proteins to Breast Cancer by Local Administration of Functional Inclusion Bodies

Two structurally and functionally unrelated proteins, namely Omomyc and p31, are engineered as CD44‐targeted inclusion bodies produced in recombinant bacteria. In this unusual particulate form, both types of protein materials selectively penetrate and kill CD44(+) tumor cells in culture, and upon lo...

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Bibliographic Details
Published in:Adv Sci (Weinh)
Main Authors: Pesarrodona, Mireia, Jauset, Toni, Díaz‐Riascos, Zamira V., Sánchez‐Chardi, Alejandro, Beaulieu, Marie‐Eve, Seras‐Franzoso, Joaquin, Sánchez‐García, Laura, Baltà‐Foix, Ricardo, Mancilla, Sandra, Fernández, Yolanda, Rinas, Ursula, Schwartz, Simó, Soucek, Laura, Villaverde, Antonio, Abasolo, Ibane, Vázquez, Esther
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6755514/
https://ncbi.nlm.nih.gov/pubmed/31559131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/advs.201900849
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