BET inhibition is an effective approach against KRAS-driven PDAC and NSCLC

Effectively treating KRAS-driven tumors remains an unsolved challenge. The inhibition of downstream signaling effectors is a way of overcoming the issue of direct targeting of mutant KRAS, which has shown limited efficacy so far. Bromodomain and Extra-Terminal (BET) protein inhibition has displayed...

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Библиографические подробности
Опубликовано в: :Oncotarget
Главные авторы: Jauset, Toni, Massó-Vallés, Daniel, Martínez-Martín, Sandra, Beaulieu, Marie-Eve, Foradada, Laia, Fiorentino, Francesco Paolo, Yokota, Jun, Haendler, Bernard, Siegel, Stephan, Whitfield, Jonathan R., Soucek, Laura
Формат: Artigo
Язык:Inglês
Опубликовано: Impact Journals LLC 2018
Предметы:
Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5922351/
https://ncbi.nlm.nih.gov/pubmed/29721157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24648
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