A Low-Toxicity DNA-Alkylating N-Mustard-Quinoline Conjugate with Preferential Sequence Specificity Exerts Potent Antitumor Activity Against Colorectal Cancer

Efficacy and safety are fundamental prerequisites for anticancer drug development. In the present study, we explored the anti–colorectal cancer (CRC) activity of SL-1, a DNA-directed N-mustard-quinoline conjugate. The N-mustard moiety in SL-1 induced DNA strand breaks, interstrand cross-links (ICLs)...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Neoplasia
Prif Awduron: Chen, Tai-Lin, Lin, Yi-Wen, Chen, Yan-Bo, Lin, Jing-Jer, Su, Tsann-Long, Shen, Chia-Ning, Lee, Te-Chang
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Neoplasia Press 2017
Pynciau:
Original article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5884014/
https://ncbi.nlm.nih.gov/pubmed/29247884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2017.11.006
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