A Low-Toxicity DNA-Alkylating N-Mustard-Quinoline Conjugate with Preferential Sequence Specificity Exerts Potent Antitumor Activity Against Colorectal Cancer

Efficacy and safety are fundamental prerequisites for anticancer drug development. In the present study, we explored the anti–colorectal cancer (CRC) activity of SL-1, a DNA-directed N-mustard-quinoline conjugate. The N-mustard moiety in SL-1 induced DNA strand breaks, interstrand cross-links (ICLs)...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Neoplasia
Main Authors: Chen, Tai-Lin, Lin, Yi-Wen, Chen, Yan-Bo, Lin, Jing-Jer, Su, Tsann-Long, Shen, Chia-Ning, Lee, Te-Chang
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press 2017
Assuntos:
Original article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5884014/
https://ncbi.nlm.nih.gov/pubmed/29247884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2017.11.006
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados