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Structure-activity relationships among DNA ligase inhibitors; characterization of a selective uncompetitive DNA ligase I inhibitor

In human cells, there are three genes that encode DNA ligase polypeptides with distinct but overlapping functions. Previously small molecule inhibitors of human DNA ligases were identified using a structure-based approach. Three of these inhibitors, L82, a DNA ligase I (LigI)-selective inhibitor, an...

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Publicat a:DNA Repair (Amst)
Autors principals: Howes, Timothy R.L., Sallymr, Annahita, Brooks, Rhys, Greco, George E., Jones, Darin E., Matsumoto, Yoshihiro, Tomkinson, Alan E.
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5881949/
https://ncbi.nlm.nih.gov/pubmed/29078112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2017.10.002
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