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SCR7 is neither a selective nor a potent inhibitor of human DNA ligase IV

DNA ligases are attractive therapeutics because of their involvement in completing the repair of almost all types of DNA damage. A series of DNA ligase inhibitors with differing selectivity for the three human DNA ligases were identified using a structure-based approach with one of these inhibitors...

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Detalhes bibliográficos
Publicado no:DNA Repair (Amst)
Main Authors: Greco, George E., Matsumoto, Yoshihiro, Brooks, Rhys C., Lu, Zhengfei, Lieber, Michael R., Tomkinson, Alan E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5042453/
https://ncbi.nlm.nih.gov/pubmed/27235626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2016.04.004
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