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DNA ligases as therapeutic targets

During DNA replication, DNA joining events link Okazaki fragments on the lagging strand. In addition, they are required to repair DNA single- and double-strand breaks and to complete repair events initiated by the excision of mismatched and damaged bases. In human cells, there are three genes encodi...

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Detalhes bibliográficos
Main Authors: Tomkinson, Alan E., Howes, Timothy R.L., Wiest, Nathaniel E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3819426/
https://ncbi.nlm.nih.gov/pubmed/24224145
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