PEDF protects cardiomyocytes by promoting FUNDC1-mediated mitophagy via PEDF-R under hypoxic condition

Pigment epithelial-derived factor (PEDF) is known to exert diverse physiological activities. Previous studies suggest that hypoxia could induce mitophagy. Astoundingly, under hypoxic condition, we found that PEDF decreased the mitochondrial density of cardiomyocytes. In this study, we evaluated whet...

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Detalhes bibliográficos
Publicado no:Int J Mol Med
Main Authors: Li, Yufeng, Liu, Zhiwei, Zhang, Yiqian, Zhao, Qixiang, Wang, Xiaoyu, Lu, Peng, Zhang, Hao, Wang, Zhu, Dong, Hongyan, Zhang, Zhongming
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2018
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5881750/
https://ncbi.nlm.nih.gov/pubmed/29512692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijmm.2018.3536
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