PEDF protects cardiomyocytes by promoting FUNDC1-mediated mitophagy via PEDF-R under hypoxic condition

Pigment epithelial-derived factor (PEDF) is known to exert diverse physiological activities. Previous studies suggest that hypoxia could induce mitophagy. Astoundingly, under hypoxic condition, we found that PEDF decreased the mitochondrial density of cardiomyocytes. In this study, we evaluated whet...

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Gepubliceerd in:Int J Mol Med
Hoofdauteurs: Li, Yufeng, Liu, Zhiwei, Zhang, Yiqian, Zhao, Qixiang, Wang, Xiaoyu, Lu, Peng, Zhang, Hao, Wang, Zhu, Dong, Hongyan, Zhang, Zhongming
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: D.A. Spandidos 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5881750/
https://ncbi.nlm.nih.gov/pubmed/29512692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijmm.2018.3536
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