PEDF protects cardiomyocytes by promoting FUNDC1-mediated mitophagy via PEDF-R under hypoxic condition

Pigment epithelial-derived factor (PEDF) is known to exert diverse physiological activities. Previous studies suggest that hypoxia could induce mitophagy. Astoundingly, under hypoxic condition, we found that PEDF decreased the mitochondrial density of cardiomyocytes. In this study, we evaluated whet...

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Publié dans:Int J Mol Med
Auteurs principaux: Li, Yufeng, Liu, Zhiwei, Zhang, Yiqian, Zhao, Qixiang, Wang, Xiaoyu, Lu, Peng, Zhang, Hao, Wang, Zhu, Dong, Hongyan, Zhang, Zhongming
Format: Artigo
Langue:Inglês
Publié: D.A. Spandidos 2018
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5881750/
https://ncbi.nlm.nih.gov/pubmed/29512692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijmm.2018.3536
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