PEDF protects cardiomyocytes by promoting FUNDC1-mediated mitophagy via PEDF-R under hypoxic condition

Pigment epithelial-derived factor (PEDF) is known to exert diverse physiological activities. Previous studies suggest that hypoxia could induce mitophagy. Astoundingly, under hypoxic condition, we found that PEDF decreased the mitochondrial density of cardiomyocytes. In this study, we evaluated whet...

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Bibliografske podrobnosti
izdano v:Int J Mol Med
Main Authors: Li, Yufeng, Liu, Zhiwei, Zhang, Yiqian, Zhao, Qixiang, Wang, Xiaoyu, Lu, Peng, Zhang, Hao, Wang, Zhu, Dong, Hongyan, Zhang, Zhongming
Format: Artigo
Jezik:Inglês
Izdano: D.A. Spandidos 2018
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5881750/
https://ncbi.nlm.nih.gov/pubmed/29512692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijmm.2018.3536
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