Cyclic mechanical tension reinforces DNA damage and activates the p53-p21-Rb pathway to induce premature senescence of nucleus pulposus cells

Intervertebral disc (IVD) degeneration (IDD) is a widely recognized contributor to low back pain. Mechanical stress is a crucial etiological factor of IDD. During the process of IDD, a vicious circle is formed between abnormal mechanical stress and the damage of disc structure and function. Notably,...

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Pubblicato in:Int J Mol Med
Autori principali: Feng, Chencheng, Yang, Minghui, Zhang, Yang, Lan, Minghong, Huang, Bo, Liu, Huan, Zhou, Yue
Natura: Artigo
Lingua:Inglês
Pubblicazione: D.A. Spandidos 2018
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5881642/
https://ncbi.nlm.nih.gov/pubmed/29512682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijmm.2018.3522
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