Transcriptome and alternative splicing analysis of nucleus pulposus cells in response to high oxygen tension: Involvement of high oxygen tension in the pathogenesis of intervertebral disc degeneration

High oxygen tension caused by neovascularization in the microenvironment of intervertebral discs (IVDs) is associated with the pathogenesis of IVD degeneration (IDD). Pre-mRNAs undergo alternative splicing (AS) to produce structurally and functionally diverse mRNA and proteins. However, the precise...

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Vydáno v:Int J Mol Med
Hlavní autoři: Feng, Chencheng, Zhang, Yang, Yang, Minghui, Lan, Minghong, Huang, Bo, Liu, Huan, Zhou, Yue
Médium: Artigo
Jazyk:Inglês
Vydáno: D.A. Spandidos 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5881661/
https://ncbi.nlm.nih.gov/pubmed/29512703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijmm.2018.3523
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