Selective deletion of PPARβ/δ in fibroblasts causes dermal fibrosis by attenuated LRG1 expression

Connective tissue diseases of the skin are characterized by excessive collagen deposition in the skin and internal organs. Fibroblasts play a pivotal role in the clinical presentation of these conditions. Nuclear receptor peroxisome-proliferator activated receptors (PPARs) are therapeutic targets fo...

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Vydáno v:Cell Discov
Hlavní autoři: Sng, Ming Keat, Chan, Jeremy Soon Kiat, Teo, Ziqiang, Phua, Terri, Tan, Eddie Han Pin, Wee, Jonathan Wei Kiat, Koh, Nikki Jun Ning, Tan, Chek Kun, Chen, Jia Peng, Pal, Mintu, Tong, Benny Meng Kiat, Tnay, Ya Lin, Ng, Xuan Rui, Zhu, Pengcheng, Chiba, Shunsuke, Wang, Xiaomeng, Wahli, Walter, Tan, Nguan Soon
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5880809/
https://ncbi.nlm.nih.gov/pubmed/29619245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41421-018-0014-5
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