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Cancer-associated fibroblasts enact field cancerization by promoting extratumoral oxidative stress

Histological inspection of visually normal tissue adjacent to neoplastic lesions often reveals multiple foci of cellular abnormalities. This suggests the presence of a regional carcinogenic signal that spreads oncogenic transformation and field cancerization. We observed an abundance of mutagenic re...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Chan, Jeremy Soon Kiat, Tan, Ming Jie, Sng, Ming Keat, Teo, Ziqiang, Phua, Terri, Choo, Chee Chong, LI, Liang, Zhu, Pengcheng, Tan, Nguan Soon
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386391/
https://ncbi.nlm.nih.gov/pubmed/28102840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.492
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