Noninflammatory Changes of Microglia Are Sufficient to Cause Epilepsy

Microglia are well known to play a critical role in maintaining brain homeostasis. However, their role in epileptogenesis has yet to be determined. Here, we demonstrate that elevated mTOR signaling in mouse microglia leads to phenotypic changes, including an amoeboid-like morphology, increased proli...

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Dettagli Bibliografici
Pubblicato in:Cell Rep
Autori principali: Zhao, Xiaofeng, Liao, Yuan, Morgan, Shannon, Mathur, Ramkumar, Feustel, Paul, Mazurkiewicz, Joseph, Qian, Jiang, Chang, Julia, Mathern, Gary W., Adamo, Matthew A., Ritaccio, Anthony L., Gruenthal, Michael, Zhu, Xinjun, Huang, Yunfei
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5880308/
https://ncbi.nlm.nih.gov/pubmed/29466735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.02.004
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