Noninflammatory Changes of Microglia Are Sufficient to Cause Epilepsy

Microglia are well known to play a critical role in maintaining brain homeostasis. However, their role in epileptogenesis has yet to be determined. Here, we demonstrate that elevated mTOR signaling in mouse microglia leads to phenotypic changes, including an amoeboid-like morphology, increased proli...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Zhao, Xiaofeng, Liao, Yuan, Morgan, Shannon, Mathur, Ramkumar, Feustel, Paul, Mazurkiewicz, Joseph, Qian, Jiang, Chang, Julia, Mathern, Gary W., Adamo, Matthew A., Ritaccio, Anthony L., Gruenthal, Michael, Zhu, Xinjun, Huang, Yunfei
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5880308/
https://ncbi.nlm.nih.gov/pubmed/29466735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.02.004
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